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Bure Strongest Evidence Yet of a Causal Relationship Between Obesity and Health Conditions
ISLAMABAD:Sarfaraz Merchant has agreed to visit Pakistan to record his statements regarding allegations against leadership of the Muttahida Qaumi Movement.Earlier during the day, interior minister directed the FIA to address concerns raised by the businessman to probe the allegations against Altaf Hussain's links with the Indian聽spy agency RAW.Merchan newbalance 550 t agreed on Monday to arrive in the country on a mutually agreed date and record his statement before a committee, sources in the agency told The Express Tribune.Earlier during the day, the London-based businessman denied having issued statements regarding the MQM chief's alleged links with India'spy agency.FIA uggs hausschuhe  seeks Kamal, Merchant's help to probe allegations against MQMThe FIA had contacted Mustafa Kamal and Merchant, seeking cooperation to probe allegations against the MQM leaders newbalance hip.On March 1, the Karachi-based trader accused the party of involvement in money laundering, criminal activities and links with RAW.Similar allegations were  Affymetrix Inc.has announced thatCase Western Reserve University and the Translational Genomics Research Institute (TGen) will use the Affymetrix Genome-Wide Human SNP Array 6.0 to discover genetic pathways associated with diabetic nephropathy (DN).Case Western is the coordinating center for the 11 centers conducting independent studies as part of the Family Investigation of Nephropathy and Diabetes (FIND) Consortium, a project launched by the National Institute of Diabetes and dunk panda  Digestive and Kidney Diseases (NIDDK) in 1999.Over a five-year period, 11 recruitment centers across the United States pooled their resources to recruit and enroll more than 10,000  nike airforce participants into the FIND study. The FIND Consortium has already identified several key genetic variants associated with nephropathy in African-Americans, European-Americans, Mexican-Americans and American Indians.Scientists expect that the results gathered using the SNP Array 6.0 nike air forces 1  will ultimately lead to therapeutic strategies to pre

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Efns N Korean colonel, diplomat defected to South: Seoul
KARACHIakistan will get its first taste of international hockey in six years when the Oman U18 team turns out at Lahore鈥檚 National Hockey Stadium today to play their Pakistani counterparts as part of the Pak-Oman U18 Hockey Series.The Mid newbalance 550 dle Eastern side arrived in Lahore yesterday and had a training session in the evening to get used to the local conditions. Pakistan U18, on the other hand, have been training since last week and seem more prepared for the series.As per Shahbaz Senior, the secretary of Pakistan Hockey Federation (PHF), the first of the four-match series will be played today during the day, while the follow-up game will be played tomorrow under floodlights.Oman to tour Pakistan for four matchesThe series will then resume after a day鈥檚 rest, with two bac adidas campus donna k-to-back matches scheduled on September 19 and 20.鈥淲e have also arranged a dinner for both teams on their day of rest so that they can interact with each other. This will not only boost the team鈥檚 confiden newbalance 530 ce but also a Primary amoebic meningoencephalitis (PAM), a deadly disease caused by the 鈥渂rain-eating amoeba鈥漀aegleria fowleri, is becoming more common in some areas of the world, and it has no effective treatment. Now, researchers reporting inACS Chemical Neurosciencehave found that a compound isolated from the leaves of a traditional medicinal plant,Inula viscosaor 鈥渇alse yellowhead,鈥?kills the amoebae by causing them to commit cell suicide in lab studies, which could lead to new treatments.PAM, characterized by headache, fever dunk nike store , vomit dunk low ing, hallucinations and seizures, is almost always fatal within a couple nike sb dunk  of weeks of developing symptoms. Although the disease, which is usually contracted by swimming in contaminated freshwater, is rare, increasing cases have been reported recently in the U.S., the Philippines, southern Brazil and some Asian countries. Amphotericin B is the most common therapy given to those with the infection. It can killN. fowleriin the lab, but it isn鈥檛 very effective when given t

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Anxq Biomillenia Leverages QIAGEN Bioinformatics in Microbiome-on-a-Chip Discovery of Unculturable Microbes
CAIRO, EGYPT:A booby-trapped motorcycle exploded outside an Egyptian police training centre on Saturday, wounding 16 people, the interior ministry said.The apparent attack in the Nile Delta city of Tanta wounded 13 policemen and three civilian passersby, the ministry said in a statement.A militant group that calls itself Liwaa al-Thawra -- The Revolution Brigade -- claimed responsibility for the bombing in a stat nb ement posted on its social media accounts.Egypt's president leaves Cairo for Washington to meet TrumpIslamist militants have killed hundreds adidas samba schuhe  of policemen and soldiers, mostly in the Sinai Peninsula, since the military overthrow of Islamist president Mohamed Morsi in 2013.Militants have killed hundreds of policemen and soldiers, mostly in the Sinai Peninsula, since the military overthrow of Islamist president Mohamed adidas samba adidas  Morsi in 2013.Most of the attacks have been claimed by the Islamic State group's Egypt franchise. A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in th yeezy e journal Science Translational Medicine.Every year,about 800 children in the USare diagnosed with neuroblastoma, an aggressive cancer of the nervous system that most frequently arises in the adrenal glands. Despite intensive chemotherapy, the disease can be difficult to cure and the prognosis is often poor. However, researchers at Lund University have now identified and tested a drug that has been shown to be very effective against neuroblas air force 1 toma.鈥淚nitially we conducted a large-scale drug screen where we examined how 500 drugs affected neuroblastoma cells from patients. Most of these medications have never before been used on patients with neuroblastoma鈥? says Karin Hansson, doctoral student and first author of the study.The researchers then obtained a "short list" of the most effe nike jordan damen ctive drugs. One

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Knzu Asthma Drug Salbutamol Inhibits Tau Filament Formation In Vitro
KARACHIakistan could soon see electric cars plying on its roads as the maker of Super Power motorcycles displayed two variants it intends to start selling within the next three months.The electric cars are currently on display at the '14th My K adidas campus nere arachi-Oasis of Harmony', a three-day exhibition that was inaugurated on Friday at  stanley brand the Karachi Expo Centre.The compact vehicles can go up to a maximum of 50kmh and would need to be charged for seven hours to travel a distance of 120kms."Its target market is not specific. People from all age groups can drive this car," N.J A nb uto Industries Marketing Executive Abdul Muqsit told The Express Tribune.Why Pakistan should switch to hybrid cars PHOTO: FARHAN ZAHEER/EXPRESS The results show that it provides good, repeatable results that can be just as useful as those provide dunk nike high d by larger, more expensive devices.The MinION is a handheld DNA-sequencing device developed by Oxford Nanopore, a spin-out company from the University of Oxford. The smallest high-throughput sequencing system currently available, the device can be plugged into any computer using a USB port, weighs just 90 grams and measures 10 centimetres in length. It works by detecting individual DNA bases that pass through a nanopore 鈥?a tiny hole in a membrane. When the DNA bases pass through or near the nanpore, they create a distinctive electrical current, allowing the device t jordan 1 mid o read long DNA sequences in a way that is not possible on most other devices.The sequencer has been made available to thousands of laboratories around the world via the MinION Access Programme, all of them keen to test the abilities o new balance f眉r damen f the small device and contribute to its future development. As part of that process, fiv

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Kszt Scientists Uncover Brain Circuits Behind Putting up a Fight or Freezing
THAILAND:It wasn't until he got to medical school that Narong Khuntikeo finally discovered what caused the liver cancer that took both of his parents' lives: their lunch.Like millions of Thais across t adidas samba schuhe he rural northeast, his family regularly ate koi pla - a local dish made of raw fish ground with spices and lime.The pungent meal is quick, cheap and tasty, but the fish is also a favourite feast for parasites that can cause a lethal liver cancer killing up to 20,000 Thais annually.Most hail from northeast, a ugg hausschuhe  large, poor region known as Isaan that has dined on koi pla for gener adidas samba adidas ations and now has the highest reported instance of the Cholangiocarcinoma (CCA) - bile duct cancer - in the world.One of the major causes of CCA is a parasitic flatworm - or fluke - which is native to the Mekong region and found in many freshwater fish. Once eaten, the worms can embed undetected in the bile ducts for years causing inflammation that can, over time, trigger the aggressive cancer, according to the Wor Sci dunk low entists at the University of Liverpool have discovered a new and important function of a toxin produced by disease-causing bacteria that could have significant implications for future vaccine design.Streptococcus pneumoniae (the pneumococcus) is a major cause of life-threatening invasive diseases such as pneumonia, septicaemia and meningitis, and is responsible for more than one million deaths every year. Key to its disease-causing success is the action of a potent toxin called pneumolysin, which works by creating 鈥榟oles鈥?in the membranes of human cells, and either killing them directly or causing significant tissue damage.Until now, scientists believed that the effects of pneumolysin resulted purely from the binding of the toxin to cholesterol in host cell membranes. A new study published in Nature Microbiology, however, shows that pneumolysin ca asics gelkayano n also bind directly to a host cell receptor on specialised immune cells to suppress the immune response new balance 550 .The study was a collaboration bet

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Hpoj Rs70 million earmarked for defence expo
KARACHI:In a coordinated move, activists and organisations working for regional peace launched the 鈥楶eace Now and Forever鈥?campaign simultaneously in various cities of India and Pakistan on Saturday.In Pakistan, the campaign was launched by the Pakistan-India People鈥檚 Forum for Peace and Democracy. The launch was held at the Karachi Press Club, where campaign founder and Human Rights Commission of Pakistan representative Asad Iqbal Butt and other activists shared details of the campaign.Butt said the campaign was conceived with the objective of addressing deteriorating relations between Pakistan and India as well as to provide platforms to enable common citizens to demand peace and condemn attempts at war mongering without being apologetic or feeling guilty about their stance.He shared that Nobel laureates nb  Malala Yousufzai and Kailash Satyarthi are also joining the campaign.Peace and development: Pakistan has made unprecedented p ugg fellboots rogress since 2013, adidas campus 00s  says ShehbazButt shared that apart fr A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease. As part of the immune system, these cells have a protective function against fibrosis and liver cirrhosis. At the same time, they are useful as biomarkers of liver disease progression a af1 s they can be measured by a blood test. The results were recently published in the renowned "Journal of Hepatology new balances 480 ".Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver  adidas yeezys diseases worldwide and is estimated to affect about 30% of the European population. Chronic non-alcoholic fatty liver disease can develop into irreversible liver cirrhosis, which can only be cured by liver transplantation. Therefore, it is particularly important to identify patients with non-alcoholic fatty liver disease early on.The pathogenesis (development) of non-alcoholic fatty liver disease, especially advanced steatohepatitis (NASH, also: non-alcoh

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Huem Plasticell, CellSpring Collaborate
KARACHI:Sharmeen Obaid-Chinoy slammed critics by bagging a second Oscar. Fittingly,聽 her choice of outfit for the ceremony was also a reflection of Pakistan鈥檚 vibrant fashion industry. Compared to her previous knockout beige Bunto Kazmi Oscar outfit, this Sana Safinaz-desi adidas campus herren gned black, demure number was a tad understated, perhaps hinting at a more confident and experienced Oscar nominee. This is probably why the film-maker chose a darker suit than the one she wore for the 2012 Vanity Fair Oscar party.It is every designer鈥檚 dream to dress a celebrity fo adidas campus homme r the Academy Awards and this year Obaid-Chinoy picked the label Sana Safinaz to create an ensemble for her moment of glory. While talking to The Express Tribune, Safinaz Muneer, the label鈥檚 creative design head, says, 鈥淭o design a couture outfit, it takes a lot of brainstorming. We relied on two things, namely what the client wanted and our vision. That鈥檚 how we m new balance bleu anaged to put together this piece.鈥漁baid-Chinoy鈥檚 black-on-black outfit compr Many drugs are derived from natural products. But before natural products can be exploited, chemist yeezys slide s must first determine their structure and stereochemistry. This can be a major challen nike dunk high ge, particularly when the molecules cannot be crystallized and contain only few hydrogen atoms. A new NMR-based method, developed at the Leibniz-Forschungsinstitut f眉r Molekulare Pharmakologie (FMP), now simplifies the analysis and produces more accurate results. The work has been published in theJournal of the American Chemical Society.Natural products are present in antibiotics, painkillers and cancer drugs, playing a key role in around 60 percent of all FDA approved drugs. Plants, fungi and sessile marine organisms are  dunk particularly promising sources, because many of them possess chemical defenses to deter predators. However, identification of potential drug candidates is a challenge. First, researchers must accurately determine the structure and stereochemistry (the spatial arrangement of atoms) of t

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Brwv RCB approves Rs2.723b balanced budget
DUBAI:A Bahraini court on Thursday jailed 19 Shias for attacks against police in the Sunni-ruled kingdom, including five for life sentences, a judicial new balance homme  source said.In the first case, the five men who got the longest terms were convicted o stanley cup f a bomb attack in a Shia-populated village east of Manama in August last year.The bomb exploded when a police bulldozer was clearing barricades that had been erected by protesters, the source said.Saudi arrests Shia imam for 'glorifying' HezbollahIn the second trial, the same court handed out jail terms of between three and 15 years to 14 Shia convicted of attacki adidas campus rose ng police in Sitra, south of the capital.They were also found guilty of possessing weapons and explosives, the source said.The tiny Gulf state has been shaken by unrest since it quelled a month-long, Shia-led uprising demanding reforms in 2011.Bahrain jails 8 for life over 'terrorism'The Shia-majority kingdom, connected to Saudi Arabia by a causeway, lies across the Gulf from Shia Iran and is Sanofi and DiCE Mole converse allstar cules, a newly-launched, privately held company developing a next generation approach to small molecule drug discovery, has announced a five-year global collaboration to discover potential new therapeutics for up to 12 targets that encompass all disease areas of strategic interest to Sanofi. Th jordan4 e collaboration builds upon DiCE's unique technology platform, which leverages directed evolution to select and optimize low molecular weight compounds against any target. The platform's capabilities include the potential to unlock protein-protein interfaces that were previously unreachable for oral therapies.The collaboration is a part o new balance 574 f Sanofi's Sunrise Initiative, a strategic partnership model that seeks to invest in early stage transformative opportunities that align with Sanofi's expert development and commercialization abilities. A joint steering committee comprised of Sanofi and DiCE representatives will oversee the initiative."In the past, targeting protein-protein in

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Vzym Offshore companies: ANP chief opposes demand of PM s resignation
KARACHI:With their hopes of bagging gold all but over, Pakistan take on arch-rivals India in the Sultan Azlan Shah Cup at the Azlan Shah Stadium in Ipoh, Malaysia today vying to make th adidas schuhe campus e stanley-cup  top four and contest for a bronze medal.The Pakistan-India rivalry, be it in cricket, hockey or any other sport, always attracts huge interest. And despite both teams failing to live up to the standards expected of them in the past few years, a Pakistan-India encounter never fails to be a head-turner at any tournament.Three-time winners Pakistan missed the last two editions of the tournament, while India, champions on five occasions, finished with a bronze medal last year.Embarrassing  ugg boots damen display: We鈥檒l bounce back from this setback, says head coachPakistan have won only one out of three matches in the tournament 鈥?defeating Canada 3-1; losing to New Zealand and Australia 5-3 and 4-0 respectively. India, meanwhile, have won two out of their three matches 鈥?defeating Canada 3-1 and Japan 2-1; losing to Aust BrainStorm Cell Therapeutics Inc. has announced that the company has secured the funding required to complete pre-clinical trials underway for the treatment of ALS (Amyotrophic Lateral Sclerosis, also known as Lou Gehrig鈥檚 disease). The company expects to begin Phase I clinical studies in 2010.The new funding includes both a prestigious grant from the Israeli government鈥檚 Office of the Chief Scientist (OCS) as well as private investment.鈥淲e are very gratified to receive these financial votes of confidence in our breakthrough stem cell technology. yeezy 500  The new funding will enable us to complete our pre-clinical studies in ALS and meet our goal of beginning clinical studies in the coming year asics laufschuhe ,鈥?said Rami Efrati, CEO of BrainStorm.The non-equity OCS grant amounts up to $450,000.and marks the third consecutive year in which BrainStorm has been selected as a recipient. The company previously was awarded OCS gran nike dunk low ts totaling $798,000. BrainStorm鈥檚 royalty obligations to the OCS are capped at the a

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Trtk Faisal Raza Abidi sent to jail for two weeks
DOHAatar's emir congratulated Saudi Arabia's newly-appointed Crown Prince Mohammed bin Salman on Wednesday and called for "brotherly relations" between the two countries, currently locked in a bitter diplomatic dispute.Saudi king appoints son as crown prince in major reshuffleState media i new balance homme n the gas-rich Gulf state said Emir Sheikh Tamim bin Hamad Al-Thani had sent a cable of congratulations to the Saudi leadership.The message was sent to King Salman "on the occasion of the selection of  newbalance 9060 his royal highness Prince Mohammed bin Salman bin Abdulaziz Al-Saud as Crown Prince", said the Qatar News Agency.The statement also expressed hopes of "brotherly relations between the two brotherly countries". A message of congratulations was also posted on social media.Earlier this month, Saudi Arabia and a number allies including the United Arab Emirates, Bahrain and Egypt s ugg fellboots evered all links with Qatar over accusations that Doha supports extremism.Morocco says will send food to Qatar after Gulf states A novel messenger RNA (mRNA)-based therapy has delivered promising results for treating ovarian cancer and cachexia 鈥?a muscle-wasting condition 鈥?when tested in animals.  Using mRNA to treat ovarian cancer  In late 2020, the first mRNA-based vaccine received emergency use authorization for COVID-19. Decades of studies exploring the therapeu dunk nike low tic value of RNA preceded this announcement, with cancer treatment being a focus of much r dunk nike high esearch.   What is mRNA?  mRNA is the 鈥渕iddleman鈥?between DNA code and proteins. Through the process of transcription, DNA templates are used t converse all star o create a single strand of mRNA, which can travel beyond the nucleus of a cell and into the cytoplasm. Here, mRNA is used to build proteins based on that specific mRNA sequence through a process called translation.