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Mlwl A New Model Proposes an Autoimmune Model of Alzheimer s
  AMS Synaffix BV has announced that it has entered into a Commercial License Agreement with ADC Therapeutics for its proprietary GlycoConnect鈩?and HydraSpace鈩?site-specific antibody drug conjugate technolo air force 1 damen gies. Under the terms of the agreement, ADC Therapeutics has been granted a single-target license for one of its preclinical programs and has also been granted an option to take a limited number of additional single-target licenses for potential future programs.Floris van Delft, CSO at Synaffix said, 鈥淲e are delighted that ADC Therapeutics has recognized the value of our propr nike dunk sb ietary antibody-drug conjugate technologies and has elected to incorporate Synaffix technology into one of its preclinical programs.鈥濃€淭he experience adidas yeezys  of Synaffix and its partners has consistently confirmed that, in preclinical models, our proprietary GlycoConnect鈩?and HydraSpace鈩?technologies significantly improved both efficacy and safety as compared to other mainstream site-specific conjugation approaches.鈥濃€淲e lo  Just days after the launch of Pakistan International Airlines (PIA) Premier, passengers 'damaged'聽a London-bound flight.Upon its arrival in London on Wednesday,聽one of the adidas samba og  recently inducted聽A-330s looked nothing like a new plane as people had thrown litter everywhere and stolen bottles of lotion.PM inaugurates PIA's premier servicePIA Spokesperson Daniyal Gilani took to Twitter to post pictures of PK-785聽on its arrival in London.聽"This is how our new A-330 looked like on arrival in London yesterday. Litter. Lotions stolen. Passengers please take care of PIA premier," he wrote.This is how r new A330 lookd like upon arrival in Lon yest. Litter.Lotions stolen. Pax plz take care of #PIAPremier pic.twitter.com/GdZBhCmA00&m ugg fellboots dash; Digi Fusion (@DigiFusion24) August 18, 2016Whoever stole the lotion was travelling on Business class. And yes Pakistanis littered the plane on 1st flight. https://t.co/3ScZ ugg mini FQgxjd— Tahir Imran Mian 鉁?(@TahirImran) August 18, 2016Responding to questions regarding

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Cide Huge Advancements Made in Solid-State Battery Technology
  AMRI has an yeezys nounced that its Burlington, Mass., site has received approval to expand its current U.S. Drug Enforcement Administra dunk homme tion (DEA) registration to handle Schedule 2 and 2N controlled substances.The license represents the DEA鈥檚 acknowledgement of Burlington鈥檚 physical security and quality systems, including inventory control and documentation.With its cGMP aseptic formulation and filling expertise, AMRI Burlington supports pre-clinical through commercial scale production of liquid-filled and lyophilized parenterals.The addition of Schedule 2 compounds to this registration allows Burlington to perform controlled substance work for its customers, both in the laboratory and on the engineering/production side.Steven R. Hagen, Ph.D., Senior Vice President of Pharmace yeezy 500 utical Development and Manufacturing at AMRI, said, 鈥淎s part of its fully integrated global contract services offering, AMRI has the expertise to support cGMP production for a wide spectrum of products across platform tec  I samba adidas og SLAMABAD:Interior Minister Chaudhry Nisar on Saturday lashed out at Pakistan Peoples Party for criticising his meetings with leaders of proscribed organisations.Addressing the media in Kallar Syedan Nisar said, "It is unfair to link everything to the chief of the proscribed Ahle Sunnat Wal Jamaat (ASWJ) Maulana Ahmad Ludhi颅anvi."Shocking!Defending his meetings, he聽said, "Everyone knows the issues PPP has with me." Admitting that there are photographs of him meeting leaders of proscribed organisations, the interior minister question adidas campus 00's ed if PPP leaders during their tenure did not meet the leaders.Referring to the action taken against people bearing fake聽Computerised National Identity Cards (CNICs), the interior minister said, "Duri new balance pour homme ng my tenure, about 450,000 CNICs and聽32,400 passports have been blocked. There is no record of a single CNIC being blocked from 2002 till 2007, which reflects on negligence of previous governments."Offered to resign over SC report on Quetta carnage: NisarOn Tue

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Lmcb Anacor Pharmaceuticals Announces Its Partner GSK Voluntarily Paused Clinical Trials
  A new helper in the fight against cancer and oth adidas yeezy er diseases of the gut may be genetically altered bacteria that release medicines to tumors or the gut.Now, a new study performed using mice demonstrates how doctors might one day better regulate those the nike dunk sb rapeutic microbes by engineering them to respond to temperature. For instance, if engineered bacteria were administered to a patient with a disease, doctors could, in theory, instruct the bacteria to release medicine to just the site of interest, and nowhere else in the body, by using ultrasound to gently heat up the tissue."Bacteria can be designed to act like special agents fighting disease in our bodies," says Caltech's Mikhail Shapiro, assistant newbalance 530  professor of chemical engineering and Heritage Principal Investigator, whose overall research goal is to create new ways to both visualize and control cells 鈥?bacterial cells and human cells 鈥?for medicinal purposes. "We're building walkie-talkies for the cells so we can both listen and talk   The government has admitted that power companies have been plagued with losses caused by a multitude of reasons, which has led to a reduction in electricity generation and, in eff adidas samba donna ec adidas campus verdi t, resulted in prolonged outages. The Ministry of Water and Power, at a meeting of the Economic Coordination Committee (ECC), admitted that companies were finding it hard to clear dues of the Central Power Purchasing Agency. This admission comes amid the PML-N鈥檚 repeatedly-stressed promise that it would end power cuts by the end of its five-year tenure, an assurance on which  new balance bleu it is building its campaign for the upcoming elections. In three years of its term so far, the energy crisis has persisted with landmark deals doing little to reduce power outages. While the country may have moved on the road to recovery, early signs suggest the journey would be a long, arduous one with literally all stakeholders needing to play their part.Has it happened though? The government has cut down its subsidy for the power sect

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Lvyv A Single Dose of Alcohol Can Permanently Alter the Neuronal Mitochondria
  Research by University at Buffalo biologists is providing new insights into alpha-synuclei nike dunks donna n, a small acidic protein associated with Parkinson asics outlets 鈥檚 disease.Alpha-synuclein is known to form abnormal clumps in the brains of patients with Parkinson鈥檚, but scientists are still trying to understand how and why this happens.The new study, led by University of Buffalo biologist Shermali Gunawardena, explores alpha-synuclein鈥檚 basic properties, with a focus  dunk nike low on a section of the protein known as the non-amyloidal component (NAC). The research was done on fruit fly larvae that were genetically engineered to produce both normal and mutated forms of human alpha-synuclein.Some of the key findings include:The NAC region appears to aid alpha-synuclein in moving through pathways called axons that run from one area of a neuron to another. When the NAC region was missing, alpha-synuclein did not move within axons.Alpha-synuclein that鈥檚 missing the NAC region may help to prevent unwanted aggregates of the pro  The board of an affiliate newbalance  of South Korea's Lotte Group approved a land swap with the government on Monday that will enable authorities to deploy a controversial US missile defence system, the defence ministry said.The government decided last year to deploy the US Terminal High Altitude Area Defence (THAAD) system in response to the North Korean missile threat, on land that is part of a golf course owned by  samba adidas og Lotte in the Seongju region, southeast of Seoul.Strengthening defencesThe board of unlisted Lotte International Co Ltd approved the deal with the government, and the ministry and Lotte were due to sign an agreement as early as Tuesday, the ministry said.Lotte could not be immediately reached for comment.South Korea has said it and the United States aim to make the system operational by the end of the year. A South Korean military official said last week the deployment could be completed by August.But China objects to the deployment in South Korea of t ugg ultra mini he THAAD, which has a powerful ra

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Wlca Preserving heritage: Songs of Pamir ring at Lok Virsa
  Bacteraemia, bacterial infection of the bloodstream, is a major cause of illness and death in sub-Saharan Africa but little is known about whether human genetics play a part. The leading bacterial cause of death in young children worldwide is Streptococcus pneumoniae (pneumococcus), and 14.5 million episodes of serious pneumococcal disease occ dunk femme ur in young children annually.A global network of researchers, coordinated f dunk chaussure rom the Wellcome Trust Centre for Human Genetics in Oxford, therefore carried out a genome-wide association study to identify which genes might be associated with an increased likelihood of developing bacteraemia.Dr Anna Rautanen from the Wellcome Trust Centre for Human Genetics at Oxford, said: 'A key question is why only a proportion of individuals develop invasive disease despite widespread exposure and  asics gel asymptomatic carriage of bacteria. We know that genetic differences contribute to individuals' chances of developing more serious disease. However, the relevant genes fo  ISLAMABAD:Even though billions of rupees have been spent over the p new balance 327 roject, the completion of work on the new Islamabad international airport appears nowhere in sight as the Civil Aviation Authority (CAA) on Wednesday failed to give the Public Accounts Committee (PAC) a definitive deadline.While giving a special briefing to the parliamenta newbalance 574 ry panel on the project, CAA Director General (DG) Asim Suleiman said work on the airport would finish by mid-2017. However, PAC members raised eyebrows over Suleiman鈥檚 commitment and gave him one more chance to come up with a final date.New Islamabad airport: Over Rs16b approved for acquiring land鈥淭here are no roads, no water and no electricity [in the area  adidas campus blu where the airport site is located]鈥?are you sure the project will be finished [by 2017]鈥?I challenge you it will not,鈥?said Pakistan Tehreek-e-Insaf鈥檚 Arif Alvi.鈥淲e don鈥檛 want to just grill people at this forum,鈥?said PAC Chairman Khursheed Shah. 鈥淸But] we do not like to be made fools of. It is unl

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Edtv PPP in Mohmand: Minority women wing formed
  Why does your favorite T-shirt fade over time in the sun? Why do you get sunburn and why does autumn herald with brown leaves? These questions all have one thing in common: the interplay between dye pigments and the oxygen in the air. Every child at school gets to know this chemical reaction of 鈥渙xidation鈥?in the air we breathe. What else is there to research? For example, the fundamentals for a microscopic understanding of the oxidation reaction, which researchers at the University of Regensburg want to get to the bottom of.Oxygen is an amazing molecule, it's magnetic. In liq asics gelkayano uid form, it c yeezy 350 an be lifted up with a magnet like iron filings. This property has something to do with the  nike dunks electrons in oxygen. All molecules consist of atomic nuclei and electrons, which in turn behave like tiny compass needles. Usually the compass needles of the electrons are opposite in pairs so that their magnetic forces cancel each other out. But in the oxygen molecule, which consists of two oxygen atoms, both  AUSTIN/KARACHI:Global technology giant Crossover ran a successful hiring t adidas samba ournament in Karachi, with the aim of hiring the best talent from Pakistan.Crossover hires through a gaming tournament approach, where programmers are tasked to go t adidas campus pink hrough a multiple round competition based on technical knowledge and a solution approach. More than 300 programmers in Dot Net and Java technology applied in the competition.The winners of the tournament will be offered job contracts with an annual starting salary of $100,000 per person.In the message to participants, Crossover Chief Executive Officer Andy Tryba  adidas samba nere said the company was planning to run more tournaments across Pakistan and were planning to hire over 200 senior software architects in the country.鈥淲e aim to bring an additional $20 million per annum worth of employment to Pakistan鈥檚 economy this year,鈥?he said.Earlier this year, Crossover hired eight senior software architects in Lahore. The next round will be held in Islamabad.10 tech compan

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Bhod Pakistan-born Italian jailed for 18 years for trying to board flight with pipe bomb
  Scie converse all star ntists believe the solar system was formed some 4.6 billion years ago when a cloud of gas and dust collapsed under gravity possibly triggered by a cataclysmic explosion from a nearby massive star or supernova. As this cloud collapsed, it formed a spinning disk with the sun in the center. Since then scientists have been able to establish the formation of the solar system piece by piece. Now, new research has enabled scientists from The University of New Mexico, Arizona State University and NASA's Johnson Space Center to add another piece to that puzzle with the discovery of the oldest-ever dated igneous meteorite.The research titled, Silica-rich volcanism in the Early Solar System Dated at 4.565 Ga (billion years), was published today in Nature Communications. This newbalance 530  research provides direct evidence that chemically evolved silica-rich crustal rocks were forming on planetsimals within the first 10 million years prior to the assembly of the terres yeezy 350 trial planets and helps scientists furt  IS ugg ultra mini LAMABAD:The director-general and all officials of the NADRA were suspended on Friday on charges of gross violations of Public Procurement Regulatory Authority (PPRA) rules in hiring an office building on rent. The decision was taken by Interior Minister Chaudhry Nisar Ali Khan after the Federal Investigation Agency (FIA) submitted an inquiry report d adidas campus rose etailing the shady nature of contract and exorbitant rent. Chairing a meeting, also attended by NADRA鈥檚 board members, the interior minister also directed NADRA officials to refrain from hiring buildings on rent. He also tasked NADRA to identify government lands for establishing permanent infrastructure within a month. Th ugg boots f眉r damen e building in question was hired by NADRA for a rent of Rs4.5 million a month with payment of 18-month rent in advance.聽 The minister also directed the NADRA management to digitise its complaint system.Published in The Express Tribune, October 8th, 2016.

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Wzsp Breast Cancers Boost Growth by Remotely Disrupting Immunity in Animal Models
  Understanding the processes initiated by this mechanism could h air force 1 damen elp scientists more efficiently convert stem cells into endothelial cells for use in tissue repair, or for engineering blood vessels to bypass blockages in the heart.The report, publ new balance f眉r damen ished online in the journal Stem Cell Reports, identifies two enzymes that alter the expression of certain  asics laufschuhe genes needed for embryonic cells to differentiate and become endothelial cells.The enzymes work by an 鈥渆pigenetic鈥?modification 鈥?a chemical change to DNA, or certain proteins that interact with DNA, that changes the activity of genes without changing the DNA itself. Changes to the proteins around which DNA is wound, called histones, can up-regulate the expression of genes by exposing them to the cellular machinery that translates their DNA.鈥淓pigenetic modifications to histones can trigger the activation of a large number of genes simultaneously, instead of regulating one gene at a time,鈥?says Jalees Rehman, associate professor of medicine   NEW DELHI:India has decided to put on hold all bilateral exchanges with Pakistan in reaction to a military court鈥檚 verdict sentencing Kulbhushan Jadhav, an Indian national accused of espionage, to death.The Times of India (TOI) reported that the Indian government on Friday called off talks between the two neighbouring countries on maritime security which was scheduled to be held on April 17.Self-confessed Indian spy awarded death sentenceNew Delhi officially told Pakis stanley tan that it was not ready to host a delegation from Pakistan Maritime Security Agency (PMSA) which was likely to travel to India on Sunday, claimed the Indian newspaper."The Indian high commission in Islamabad has conveyed to the Ministry of Foreign Affairs that the MSA-ICG  new balance femme meeting scheduled to be held in Delhi on (April) 17th has been postponed," Pakistan High Commission Spokesperson nb 9060  Khawaja Maaz Tariq has also confirmed according to the TOI.The Coast Guard interestingly seemed prepared for the talks as late as Friday mo

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Ntcc Mangoes in cartons banned at govt offices聽in Sindh
  4SC A yeezy 500 G has announced that the company has further strengthened the patent protection for its lead anti-cancer compound resminostat.The US Patent Office has granted the pat new balance 574 ent for resminostat's manufacturing process. The patent, which runs until 20 July 2029, protects the chemical process used in the manufacture of resminostat. This constitutes an additional obstacle for potential competitors while further extending the total term of resminostat's portfolio of property rights.Overall, this means the resminostat manufacturing process is protected until 2029 in almost all key markets around the world, including Europe, Japan, China, Russia, Hong Kong, Singapore and Australia - and now the USA.This supplements wo dunk nike low rldwide protection for resminostat's strategically important composition-of-matter patent, which was achieved on a global basis already in 2013.Enno Spillner, Chief Executive Officer of 4SC, said: "We are pleased to announce the protection of the resminostat manufacturing method in  Loo uggs hausschuhe k at adidas samba adidas  wha nb balance t we keep on the top of our list

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Tfjc Closing the door: YDA to shut down OPDs at govt hospitals
  Chances are good that a medication you take is one of several drugs that can be affected by genetic factors, according to researchers at聽Washington University School of Medicine in St. Louis and the St. Louis College of Pharmacy. They found that 29 percent of patients seen at local primary-care offices had taken at least one of 16 drugs that can cause adverse reactions in genetically susceptible people.Finding that so many primary-care patients use such medica yeezy damen tions suggests that pharmacogenetics - the study of the interplay between genes and drugs - has the potential to benefit a large portion of the population, according to the researchers. Applying information from pharmacogenetics to primary-care practices could reduce the incidence of adverse reactions and optimize treatments, according to the stud asics gel 1130 y, published in the January 2006 issue of the journal Pharmacogenomics. "Until now, researchers looking at the role of nike high dunk  genetic variation in drug effects have focused mainly on toxic drugs  LAHORE:Six police officials, including an ins ugg pector, a sub-inspect adidas campus rouge or and an assistant sub-inspector, and two guards of the Evacuee Trust Property Board were injured in a clash over an attempt to recover trust land from illegal occupants in Kot Sanat Ram, Nankana Sahib.ETPB Chairman Siddiqul Farooq said that the illegal occupants were being backed by Provincial Assembly Member (MPA) Zulqarnain Dogar. He said the ETPB and the police team were attacked by people associated with the squatters. He said some of them had thrown bricks and stones at the ETPB-police team and others had charged the officials with batons.Later, he said, some of the attackers had shot at the officials. He said he had dodged a bullet shot at him.聽 His car was damaged.Farooq said the ETPB had recovered ugg  400 kanals of trust land from illegal occupants last year. He said a total of 19,000 acres of land managed by the ETPB had been illegally occupied across the province. 鈥淚鈥檓 in charge of the trust. I won鈥檛 let anyone i